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1.
Sci Rep ; 14(1): 6001, 2024 Mar 12.
Artigo em Inglês | MEDLINE | ID: mdl-38472232

RESUMO

The rapid progress that plasma wakefield accelerators are experiencing is now posing the question as to whether they could be included in the design of the next generation of high-energy electron-positron colliders. However, the typical structure of the accelerating wakefields presents challenging complications for positron acceleration. Despite seminal proof-of-principle experiments and theoretical proposals, experimental research in plasma-based acceleration of positrons is currently limited by the scarcity of positron beams suitable to seed a plasma accelerator. Here, we report on the first experimental demonstration of a laser-driven source of ultra-relativistic positrons with sufficient spectral and spatial quality to be injected in a plasma accelerator. Our results indicate, in agreement with numerical simulations, selection and transport of positron beamlets containing N e + ≥ 10 5 positrons in a 5% bandwidth around 600 MeV, with femtosecond-scale duration and micron-scale normalised emittance. Particle-in-cell simulations show that positron beams of this kind can be guided and accelerated in a laser-driven plasma accelerator, with favourable scalings to further increase overall charge and energy using PW-scale lasers. The results presented here demonstrate the possibility of performing experimental studies of positron acceleration in a laser-driven wakefield accelerator.

2.
Stroke ; 32(11): 2602-8, 2001 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-11692024

RESUMO

BACKGROUND AND PURPOSE: Using confirmatory factor analysis, this study evaluates the relative impact of motor, cognitive, and perceptual deficits on functional autonomy with 100 elderly (aged 55 to 79 years) victims of stroke. METHODS: Two different approaches were used for measuring functional autonomy: the Functional Autonomy Measurement System (Système de Mesure de l'Autonomie Fonctionnelle [SMAF]) and the Assessment of Motor and Process Skills (AMPS). RESULTS: The results of the confirmatory factor analysis show that motor, cognitive, and perceptual factors all make a significant contribution to the variation in functional autonomy and confirm the accuracy of the model (93% of the variance is explained when the SMAF is used to measure functional autonomy, and 64% of the variance is explained when the AMPS is used). CONCLUSIONS: The factors that make the greatest contribution in explaining the variance in functional autonomy are, in order of importance, the motor factor, the perceptual factor, and the cognitive factor.


Assuntos
Transtornos Cognitivos/fisiopatologia , Transtornos das Habilidades Motoras/fisiopatologia , Transtornos da Percepção/fisiopatologia , Acidente Vascular Cerebral/fisiopatologia , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Modelos Neurológicos , Qualidade de Vida
3.
Brain Cogn ; 43(1-3): 17-21, 2000.
Artigo em Inglês | MEDLINE | ID: mdl-10857655

RESUMO

Impairments of attentional focus often are claimed to be associated with lesions of the right hemisphere. Although some studies comparing right- and left-brain-damaged patients have supported this idea, others have not found differences between these patients in various attention tasks. The present study was carried out in order to further investigate the putative role of the right hemisphere in a simple reaction time task, a sustained attention task, and a phasic alertness task. Subjects were 46 patients with right-hemisphere lesions and 37 patients with left-hemisphere lesions. Results showed no difference between right- and left-brain-damaged patients in simple reaction time, in speed of response over time (sustained attention), and in the capacity to prepare to an uncoming stimulus (phasic alertness). Future studies will have to use a more precise categorization of lesions than only right-versus left-brain damage.


Assuntos
Nível de Alerta/fisiologia , Atenção/fisiologia , Lesões Encefálicas/fisiopatologia , Lateralidade Funcional/fisiologia , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Tempo de Reação
4.
Cortex ; 35(5): 629-45, 1999 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-10656632

RESUMO

This article presents a brain-damaged patient (RR) suffering from cognitive deficits following neurological insults, who showed a selective impairment in number transcoding. Except for written verbal numeral to arabic transcoding, his ability to transcode numerals, including writing arabic numerals to dictation, is largely preserved. Other number processing skills, including numeral recognition, numeral comprehension, and calculation, were unimpaired. Semantic and asemantic models of number processing cannot easily account for the patient's performance and it is suggested that the number transcoding system should include different code-dependent pathways for arabic transcoding from spoken verbal numerals and from written verbal numerals. Since the errors produced in the impaired transcoding rely upon the syntactical structure of numeral stimuli, it is also proposed that transcoding code-dependent pathways should reflect the structure of the verbal numeral system, especially the difference between sum and product relationships.


Assuntos
Encéfalo/fisiopatologia , Transtornos Cognitivos/diagnóstico , Transtornos Cognitivos/fisiopatologia , Vias Neurais/fisiologia , Comportamento Verbal/fisiologia , Idoso , Transtornos Cognitivos/etiologia , Humanos , Masculino , Matemática , Acidente Vascular Cerebral/complicações , Escalas de Wechsler
5.
Environ Manage ; 21(3): 359-65, 1997 May.
Artigo em Inglês | MEDLINE | ID: mdl-9106411

RESUMO

/ It has been suggested that the general public should be moreinvolved in environmental policy and decision making. It is important forthem to realize that they will have to live with the consequences ofenvironmental policies and decisions. Consequently, policy makers shouldconsider the concerns and opinions of the general public before makingdecisions on environmental issues. This raises questions such as: How can weintegrate the perceptions and reactions of the general population inenvironmental decisions? What kind of public participation should weconsider? In the present study, using a new regional ecosystem model, weattempted to integrate these aspects in its decision making model byincluding the formation of an advisory committee to resolve problems relatedto waste management. The advisory committee requested the activeparticipation of representatives from all levels of the community: economic,municipal, and governmental intervenors; environmental groups; and citizens.Their mandates were to examine different management strategies available inthe region, considering all the interdisciplinary aspects of each strategy,elaborate recommendations concerning the management strategies that are mostsuitable for all, and collaborate in communication of the information to thegeneral population. The results showed that at least in small municipalitiessuch an advisory committee can be a powerful tool in environmental decisionmaking. Conditions required for a successful consultation process, such aseveryday lay language and the presence of a facilitator other than ascientific expert, are discussed.KEY WORDS: Public consultation; Environmental policies;Interdisciplinary aspects; Municipal sewage sludge management; Generalpopulation; Decision-making process

7.
Brain Cogn ; 16(1): 11-28, 1991 May.
Artigo em Inglês | MEDLINE | ID: mdl-1854467

RESUMO

Patients with visual neglect generally fail to respond to an item placed on the left of a target location, even when both stimuli are situated in the right visual field. Little is known, however, about the level of processing for the unattended items. Two patients with left visual neglect served as subjects in several experiments measuring passive contextual effects of a left-sided item on responses to a focal target. The results reveal that a neglected item may influence the speed of responding. The findings are interpreted relative to the loci of context effects in normal subjects.


Assuntos
Dominância Cerebral/fisiologia , Visão Ocular/fisiologia , Idoso , Lateralidade Funcional , Humanos , Pessoa de Meia-Idade , Estimulação Luminosa
8.
Cortex ; 26(2): 227-37, 1990 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-2387157

RESUMO

Results of a previous experiments designed to test if there is a right hemisphere superiority over the left hemisphere in the capacity to react quickly to a stimulus have not lead to an unambiguous conclusion, although the majority of studies indicate that right-brain-damaged patients are generally slower than left-brain-damaged patients. The present experiment re-examines the speed of reaction time to auditory stimulation in a population of brain-damaged patients. Each case was presented with 120 auditory events and variable inter-trial intervals (from 1 s to 15 s). To ensure homogeneity of the population tested, only patients with a cerebro-vascular accident were chosen. The results show that the right-brain-damaged patients were not generally slower than left-brain-damaged patients. However, a marked deterioration in performance over time was observed in the right-hemisphere group while a small amount of improvement was found in the normal and left-brain-damaged patients. The outcome is discussed in terms of a sustained attention deficit associated with right-hemisphere damage.


Assuntos
Dano Encefálico Crônico/fisiopatologia , Dominância Cerebral , Estimulação Acústica , Adulto , Análise de Variância , Dano Encefálico Crônico/patologia , Humanos , Tempo de Reação
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